Importins/Karyopherins Meet Nucleoporins
نویسندگان
چکیده
منابع مشابه
Importins/Karyopherins Meet Nucleoporins
with the goal of identifying the numerous nuclear pore Universitä t Heidelberg proteins and studying their role in nucleocytoplasmic Institut fü r Biochemie I transport. Recently, the purification of milligram quanti-Im Neuenheimer Feld 328 ties of highly enriched yeast NPCs and a genetic dissec-D-69120 Heidelberg tion of the NPC gave a burst of knowledge on the nature Federal Republic of Germa...
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It seems to make perfect sense that RNA, which must be exported from the nucleus to be translated, would be produced near or in association with nuclear pores. Indeed, recent reports proposed that Saccharomyces cerevisiae genes located close to the nuclear pore complex (NPC) tend to be highly transcribed [1,2] and that, upon activation, some genes relocate from the nuclear interior to the nucle...
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An evolutionary advantage of intrinsically disordered proteins (IDPs) is their ability to bind a variety of folded proteins-a paradigm that is central to the nucleocytoplasmic transport mechanism, in which nuclear transport receptors mediate the translocation of various cargo through the nuclear pore complex by binding disordered phenylalanine-glycine-rich nucleoporins (FG-Nups). FG-Nups are hi...
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ژورنال
عنوان ژورنال: Cell
سال: 1996
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81026-0